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2024 ACR guidelines on screening, treatment, and management of patients with lupus nephritis

https://doi.org/10.14412/1996-7012-2025-3-27-32

Abstract

This article presents the current guidelines of the American College of Rheumatology (ACR) on the screening, treatment, and management of patients with lupus nephritis (LN), accompanied by comments from Russian experts. The discussion includes indications for renal biopsy, a new approach to the treatment of various classes of LN using triple and dual immunosuppressive therapy, as well as recommended glucocorticoid dosages and treatment durations.

About the Authors

E. A. Aseeva
V.A. Nasonova Research Institute of Rheumatology
Russian Federation

Elena Alexandrovna Aseeva 

34A, Kashirskoye Shosse, Moscow, 115522 



S. K. Soloviev
V.A. Nasonova Research Institute of Rheumatology
Russian Federation

34A, Kashirskoye Shosse, Moscow, 115522 



E. A. Pletnev
V.A. Nasonova Research Institute of Rheumatology
Russian Federation

34A, Kashirskoye Shosse, Moscow, 115522 



A. V. Dacina
V.A. Nasonova Research Institute of Rheumatology
Russian Federation

34A, Kashirskoye Shosse, Moscow, 115522 



References

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8. American College of rheumatology. 2024 American College of Rheumatology (ACR) Guideline for the Screening, Treatment, and Management of Lupus Nephritis. https://rheumatology.org/lupus-guideline/

9. Solov'ev SK, Kozlovskaya NL, Aseeva EA et al. Lupus nephritis – modern aspects of diagnosis and therapy. Part I. Nauchno-prakticheskaya revmatologiya. 2024;62(1):55-64. (In Russ.).

10. Rovin BH, Ayoub IM, Chan TM, et al. KDIGO 2024 Clinical Practice Guideline for the management of LUPUS NEPHRITIS. Kidney Int. 2024 Jan;105(1S):S1-S69. doi: 10.1016/j.kint.2023.09.002.

11. Houssiau FA, Vasconcelos C, D'Cruz D, et al. Immunosuppressive therapy in lupus nephritis: the Euro-Lupus Nephritis Trial, a randomized trial of low-dose versus highdose intravenous cyclophosphamide. Arthritis Rheum. 2002 Aug;46(8):2121-31. doi: 10.1002/art.10461.

12. Aseeva EA, Solov'ev SK, Kozlovskaya NL, et al. Lupus nephritis. Part II, modern ideas about therapy. Nauchno-Prakticheskaya Revmatologia. 2024;62(4):377-384 (In Russ.).

13. Furie RA, Rovin BH, Garg JP, et al; REGENCY Trial Investigators. Efficacy and Safety of Obinutuzumab in Active Lupus Nephritis. N Engl J Med. 2025 Apr 17;392(15): 1471-1483. doi: 10.1056/NEJMoa2410965. Epub 2025 Feb 7.


Review

For citations:


Aseeva EA, Soloviev SK, Pletnev EA, Dacina AV. 2024 ACR guidelines on screening, treatment, and management of patients with lupus nephritis. Sovremennaya Revmatologiya=Modern Rheumatology Journal. 2025;19(3):27-32. (In Russ.) https://doi.org/10.14412/1996-7012-2025-3-27-32

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ISSN 1996-7012 (Print)
ISSN 2310-158X (Online)