Комбинация напроксена и парацетамола для контроля боли при скелетно-мышечных заболеваниях: новая классика

Хроническая боль – наиболее тягостное проявление ревматических заболеваний (РЗ), синдром, имеющий сложный комплексный патогенез и представляющий серьезную угрозу для здоровья и жизни пациента. Он развивается в случае недостаточно эффективного контроля острой боли, на фоне персистирующего воспаления, дегенеративных процессов, дисфункции ноцицептивной системы и психоэмоциональных нарушений. Ведущей стратегией анальгетической терапии при РЗ является мультимодальный подход с использованием препаратов и методов лечения, направленных на основные элементы патогенеза боли. Для обезболивания при заболеваниях суставов и позвоночника, как правило, применяются парацетамол, нестероидные противовоспалительные препараты (НПВП) и опиоиды. Одним из путей повышения эффективности противоболевой терапии является рациональная комбинация анальгетиков. В частности, сочетанное применение НПВП и парацетамола повышает результативность лечения на 30–40%. Учитывая, что большинство пациентов с РЗ – люди старших возрастных групп, имеющие коморбидные заболевания сердечно-сосудистой системы, большой интерес вызывает использование в комбинированных препаратах напроксена. Этот НПВП обладает высоким анальгетическим потенциалом и одновременно наилучшим профилем кардиоваскулярной безопасности. Поэтому новый препарат, представляющий собой комбинацию напроксена 275 мг и парацетамола 500 мг, который недавно вошел в российскую медицинскую практику, может рассматриваться как один из наиболее удачных инструментов для контроля скелетно-мышечной боли при РЗ.

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