Role of immune inflammation in the pathogenesis of osteoarthrosis and possibilities of correction of immune impairments
https://doi.org/10.14412/1996-7012-2011-705
Abstract
A great role in the pathogenesis of osteoarthrosis has been recently assigned to immune impairments, particularly to the involvement of proinflammatory cytokines (interleukin 1 (IL-1), tumor necrosis factor-α (TNF-α)) that activate catabolic processes not only in cartilage tissue, but also in the subchodral bone and other articular structures. Non-steroidal anti-inflammatory drugs, symptomatic slow-acting agents (chondroitin and glucosamine sulfate), as well as diacerein that blocks IL-1 directly and TNF-α indirectly, reduce the activity of cytokines to some extent.
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Review
For citations:
Balabanova RM. Role of immune inflammation in the pathogenesis of osteoarthrosis and possibilities of correction of immune impairments. Sovremennaya Revmatologiya=Modern Rheumatology Journal. 2011;5(4):74-78. (In Russ.) https://doi.org/10.14412/1996-7012-2011-705
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