Остеонекроз. Часть 1. Факторы риска и патогенез
Аннотация
В статье рассматриваются различные факторы риска, приводящие к развитию остеонекроза (ОН), и некоторые аспекты его патогенеза: нарушение дифференциации стромальных клеток, сосудистого обеспечения интраи экстравазального генеза, «качества» собственно костной ткани за счет генерализованного или локального остеопороза, факторов внутрисосудистого свертывания, способствующих образованию микротромбозов. Выделены основные типы ОН.
Литература
1. <div><p>Felson D.T., Zhang Y., Hannan M.T. et al. The incidence and natural history of knee osteoarthritis in the elderly. Arthr Rheum 1995;38:1500—5.</p><p>Kellgren J.H., Lawrence J.S. Radiological assessment of osteoarthrosis. Ann Rheum Dis 1957;16:494-502.</p><p>Calder J.D., Buttery L., Revell P.A. et al.Apoptosis — a significant cause of bone cell death in osteonecrosis of the femoral head. J Bone Joint Surg Br 2004; 86:1209-13.</p><p>Weinstein R.S., Nicholas R.W., Manolagas S.C. Apoptosis of osteocytes in glucocorticoid-induced osteonecrosis of the hip. J Clin Endocrinol Metab 2000; 85:2907-12.</p><p>Youm Y.S., Lee S.Y., Lee S.H. Apoptosis in the osteonecrosis of the femoral head. Clin Orthop Surg 2010;2:250-5.</p><p>Bejar J., Peled E., Boss J.H. Vasculature deprivation — induced osteonecrosis of the rat femoral head as a model for therapeutic trials. Theor Biol Med Model 2005;2:24.</p><p>Sacamoto M., Shimizu K., Iida S. et al. Osteonecrosis of the femoral head. J Bone Joint Surg Br 1997;79:213-9.</p><p>Malizos K.N., Karantanas A.H., Varitimidis S.E. et al. Osteonecrosis of the femoral head: etiology, imaging and treatment. Eur J Radiol 2007;63(1):16—28.</p><p>Mont M.A., Hungerford D.S. Non-traumatic avascular necrosis of the femoral head. J Bone Joint Surg Am 1995;77(3):459-74.</p><p>Vail T.P., Covington D.M. The incidence of osteonecrosis. In: Osteonecrosis: Etiology, Diagnosis, and Treatment. J.R. Urbaniak, J.P. Jones Jr. (eds). Rosemont, IL: American Academy of Orthopedic Surgeons, 1997;43—9.</p><p>Larson A.N., McIntosh A.L., Trousdale R.T., Lewallen D.G. Avascular necrosis most common indication for hip arthroplasty in patients with slipped capital femoral epiphysis. J Pediatr Orthop 2010;30(8):767—73.</p><p>Luedtke L.M., Flynn J.M., Pill S.G. A review of avascular necrosis in developmental dysplasia of the hip and contemporary efforts at prevention. UPOJ 2000;13:22-8.</p><p>Mont M.A., Zywiel M.G., Marker D.R. et al. The natural history of untreated asymptomatic osteonecrosis of the femoral head: a systematic literature review. J Bone Joint Surg Am 2010;92(12):2165—70.</p><p>Morse C.G., Mican J.M., Jones E.C. et al. The incidence and natural history of osteonecrosis in HIV-infected adults. Clin Infect Dis2007;44(5):739-48.</p><p>Ono K., Sugioka Y. Epidemiology and risk factors in avascular necrosis of the femoral head. In: Bone circulation and vascularization in normal and pathological conditions. A. Schourens, J. Arlet, J.W.M. Gardeniers et al. (eds). New York, 1993:241-8.</p><p>Mankin H.J. Nontraumatic Necrosis of Bone (Osteonecrosis). N Engl J Med 1992;326:1473-9.</p><p>Ficat R.P. Idiopathic bone necrosis of the femoral head: early diagnosis and treatment. J Bone Joint Surg Br 1985;67:3-105.</p><p>Hungerford D.S., Lennox D.W. The importance of increased intraosseous pressure in the development of osteonecrosis of the femoral head: implications for treatment. Orthop Clin North Am 1985;16:635-54.</p><p>Hungerford D.S. Core decompression for the treatment of avascular necrosis of the femoral head. Semin Arthrop 1991;2:182-8.</p><p>Grose A.W., Gardner M.J., Sussmann P.S. et al. The surgical anatomy of the blood supply to the femoral head: description of the anastomosis between the medial femoral circumflex and inferior gluteal arteries at the hip. J Bone Joint Surg Br 2008;90:1298-303.</p><p>Lavernia C.J., Sierra R.J., Grieco F.R. Osteonecrosis of the femoral head. J Am Acad Orthop Surg 1999;74:250-61.</p><p>Malizos K.N., Karantanas A.H., Varitimidis S.E. et al. Osteonecrosis of the femoral head: etiology, imaging and treatment. Eur J Radiol 2007;63:16-28.</p><p>Jones J.P. Fat embolism, intravascular coagulation, and osteonecrosis. Clin Orthop Relat Res 1993;292:294-308.</p><p>Jones J.P. Jr. Etiology and pathogenesis of osteonecrosis. Semin Arthrop 1997; 2:182—8.</p><p>Cui Q., Wang G.J., Su C.C., Balian G. The Otto Aufranc Award. Lovastatin prevents steroid induced adipogenesis and osteonecrosis. Clin Orthop Relat Res 1997;344:8-19.</p><p>Wang G.J., Sweet D.E., Reger S.I., Thompson R.C. Fat-cell changes as a mechanism of avascular necrosis of the femoral head in cortisone-treated rabbits. J Bone Joint Surg Am 1977;59:729-35.</p><p>Kannu P., O'Rielly D.D., Hyland J.C., Kokko L.A. Avascular necrosis of the femoral head due to a novel C propeptide mutation in COL2A1. Am J Med Genet 2011;155A:1759-62.</p><p>Korompilias V.A., Ortel L.T., Urbaniak R.J. Coagulation abnormalities in patients with hip osteonecrosis. Orthop Clin N Am 2004;35:265-71.</p><p>Arruda V.R., Belangero W.D., Ozelo M.C. et al. Inherited risk factor for thrombophilia among children with Legg-Calve'-Perthes Disease. J Ped Orthop 1999;19:84-7.</p><p>Lykissas M.G., Gelalis I.D., Kostas-Agnantis I.P. The role of hypercoagulability in the development of osteonecrosis of the femoral head. Orthopedic Rev 2012;4:73-6.</p><p>Glueck C.J., Freiberg R., Glueck H.I. et al. Hybrofibrinolysis: а common, major cause of osteonecrosis. Am J Hematol 1994;45:156-66.</p><p>Glueck C.J., Freiberg R., Tracy T. et al. Thrombophilia and Hypofibrinolysis. Pathophysiologies of Osteonecrosis. Clin Orthop Relat Res 1997;334:43-56.</p><p>Glueck C.J., Fontaine R.N., Gruppo R. et al. The plasminogen activator inhibitor-1 gene, hypofibrinolysis, and osteonecrosis. Clin Orthop Relat Res 1999;366:133-46.</p><p>Tan X., Cai D., Wu Y. et al. Comparative analysis of serum proteomes: discovery of proteins associated with osteonecrosis of the femoral head. Translational Res 2006;148:114-9.</p><p>Francis R. The protein C anticoagulant pathway and thrombosis. West J Med 1985;143:95-6.</p><p>Hirata T., Fujioka M., Takahashi K. et al. Low molecular weight phenotype of apolipoprotein(a) is a risk factor of corticosteroid-induced osteonecrosis of the femoral head after renal transplant. J Rheum 2007;34:516-22.</p><p>Fortmann S.P., Marcovina S.M. Lipoprotein(a), a clinically elusive lipoprotein particle. Circulation 1997;95:295-6.</p><p>Glueck C.J., Freiberg R., Glueck H.I. et al. Hybrofibrinolysis: а common, major cause of osteonecrosis.Am J Hematol 1994;45:156-66.</p><p>Mont M.A., Glueck C.J., Pacheco I.H. et al. Risk factors for osteonecrosis in systemic lupus erythematosus. J Rheum 1997;24:654-62.</p><p>Jones L.C., Mont M.A., Le T.B. et al. Procoagulants and osteonecrosis. J Rheum 2003;30:783-91.</p><p>Mudd S.H., Levy H.L., Skovby F. et al. The metabolic and molecular bases of inherited disease. V. 1. 7th ed. New York: McGraw-Hill. Disorders of transsulfuration, 1995;1279—327.</p><p>Mudd S.H., Skovby F., Levy H.L. et al. The natural history of homocystinuria due to cystathionine b-synthase deficiency. Am J Hum Genet 1985;37:1-31.</p><p>Holme E., Kjellman B., Ronge E. Betaine for treatment of homocystinuria caused by methylenetetrahydrofolate reductase deficiency. Arch Dis Child 1989;64:1061-4.</p><p>Fenton W.A., Rosenberg L.E., Scriver C.R. et al. The metabolic and molecular bases of inherited disease. V. 2. 7th ed. New York: McGraw-Hill. Inherited disorders of cobalamin transport and metabolism, 1995;3129—49.</p><p>Mandel H., Brenner B., Berant M. et al. Coexistence of hereditary homocystinuria and factor V Leiden-effect on thrombosis. N Engl J Med 1996;334:763-8.</p><p>Fuerer C., Nusse R., Ten Berge D. Wnt signaling in development and disease. Max Delbruck Center for Molecular Medicine meeting on Wnt signaling in Development and Disease. EMBO Rep 2008;9:134-8.</p><p>Gordon M.D., Nusse R. Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors. J Biol Chem 2006;281:22429-33.</p><p>Logan C.Y., Nusse R. The Wnt signaling pathway in development and disease. Ann Rev Cell Dev Biol 2004;20:781-810.</p><p>Macdonald B.T., Semenov M.V., He X. SnapShot: Wnt/beta-catenin signaling. Cell 2007;131:1204.</p><p>Mikels A.J., Nusse R. Wnts as ligands: processing, secretion and reception. Oncogene 2006;25:7461-8.</p><p>Moon R.T., Brown J.D., Torres M. WNTs modulate cell fate and behavior during vertebrate development. Trends Genet 1997;13:157-62.</p><p>Nusse R. Wnt signaling and stem cell control. Cell Res 2008;18:523-7.</p><p>Semenov M.V., Habas R., Macdonald B.T., He X. SnapShot: Noncanonical Wnt Signaling Pathways.Cell 2007;131:1378.</p><p>Van Amerongen R., Mikels A., Nusse R. Alternative wnt signaling is initiated by distinct receptors. Sci Signal 2008;1:9.</p><p>Li J., Sarosi I., Cattley R.C. et al. Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia. Bone 2006;39:754-66.</p><p>Morvan F., Boulukos K., Clement-Lacroix P. et al. Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass. J Bone Miner Res 2006;21:934-45.</p><p>Tian E., Zhan F., Walker R. et al. The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma. N Engl J Med 2003;349:2483-94.</p><p>Diarra D., Stolina M., Polzer K. et al. Dickkopf-1 is a master regulator of joint remodeling. Nat Med 2007;13:156-63.</p><p>Uderhardt S., Diarra D., Katzenbeisser J. et al. Blockade of Dickkopf (DKK)-1 induces fusion of sacroiliac joints. Ann Rheum Dis 2010;69:592-7.</p><p>Lane N.E., Nevitt M.C., Lui L.Y. et al. Wnt signaling antagonists are potential prognostic biomarkers for the progression of radiographic hip osteoarthritis in elderly Caucasian women. Arthr Rheum 2007;56:3319-25.</p><p>Lin C.L., Wang J.Y., Ko J.Y. et al. Dickkopf-1 Promotes Hyperglycemia-Induced Accumulation of Mesangial Matrix and Renal dysfunction. J Am Soc Nephrol 2010;21(1):124—35.</p><p>Cejka D., Herberth J., Branscum A.J. et al. Sclerostin and Dickkopf-1 in renal osteodystrophy. Clin J Am Soc Nephrol 2011;6(4):877-82.</p><p>Tаn Gang, Kang Peng-de, Pei Fu-xing. Glucocorticoids affect the metabolism of bone marrow stromal cells and lead to osteonecrosis of the femoral head: a review. Chin Med J 2012;125(1):134-9.</p><p>Ohnaka K. Wnt signaling and glucocorticoid-induced osteoporosis. Clin Calcium 2006;16(11):1812-6.</p><p>Glaw J.T., Skalak T.C., Peirce S.M. Inhibition of Canonical Wnt Signaling Increases Microvascular Hemorrhaging and Venular Remodeling in Adult Rats. Microcirculation 2010; 17(5):348—57.</p><p>Oinuma K., Harada Y., Hawata Y. et al. Osteonecrosis in patients with systemic lupus erythematosus develops very early after starting high dose corticosteroid treatment. Ann Rheum Dis 2001;60:1145-8.</p><p>Donoghue A.M. Bisphosphonates and osteonecrosis: analogy to phossy jaw. Med J 2005;183(3):163-4.</p><p>Shoback D. Update in osteoporosis and metabolic bone disorders.J Clin Endocrinol Metab 2007;92(3):747-53.</p><p>Bagan J.V., Jimenez Y., Diaz J.M. et al. Osteonecrosis of the jaws in intravenous bisphosphonate use: рroposal for a modification of the clinical classification. Oral Oncol2009;45:645-6.</p><p>Aghaloo T.L., Felsenfeld A.L., Tetradis S. Osteonecrosis of the jaw in a patient on Denosumab. J Oral Maxillofac Surg 2010;68:959-63.</p><p>Hess L.M., Jeter J.M., Benham-Hutchins M., Alberts D.S. Factors associated with osteonecrosis of the jaw among bisphosponate users. Am J Med 2008; 121(6):475-83.</p><p>Akamatsu Y., Mitsugi N., Hayashi T. et al. Low bone mineral density is associated with the onset of spontaneous osteonecrosis of the knee. Acta orthopaed 2012;83(3):249—55.</p></div><br />
Для цитирования:
Ilyinykh E.V., Барскова В.Г., Лидов П.И., Насонов Е.Л. Остеонекроз. Часть 1. Факторы риска и патогенез. Современная ревматология. 2013;7(1):17-24. https://doi.org/10.14412/1996-7012-2013-2362
For citation:
Ilyinykh E.V., Barskova V.G., Lidov P.I., Nasonov E.L. Osteonecrosis. Part 1. Risk factors and pathogenesis. Modern Rheumatology Journal. 2013;7(1):17-24. (In Russ.) https://doi.org/10.14412/1996-7012-2013-2362
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