Генно-инженерные биологические препараты в терапии системной красной волчанки
https://doi.org/10.14412/1996-7012-2013-11
Аннотация
Системная красная волчанка (СКВ) является прототипом хронического аутоиммунного заболевания. Распространенность СКВ составляет от 20 до 70 случаев на 100 тыс. женщин и варьирует в зависимости от расовой и этнической принадлежности. Несмотря на значительные успехи традиционной терапии, многие проблемы, связанные с ведением этих больных, требуют незамедлительного решения: так у 50-80% больных СКВ выявляются признаки активности и/или частые обострения, около 30% вынуждены прекратить работу, наличие IV класса волчаночного нефрита увеличивает риск развития терминальной почечной недостаточности. За последние 20 лет достигнут огромный прогресс в изучении патогенеза СКВ: найдены биологические мишени для воздействия лекарственных средств и определены принципиально новые терапевтические задачи. Белимумаб – первый генно-инженерный биологический препарат, созданный специально для лечения СКВ, что по праву рассматривается как одно из наиболее крупных достижений ревматологии за последние 50 лет.
Об авторах
Елена Александровна Асеева
ФГБУ «Научно-исследовательский институт ревматологии им. акад. В.А. Насоновой» РАМН, Москва
Россия
Россия
Сергей Константинович Соловьев
ФГБУ «Научно-исследовательский институт ревматологии им. акад. В.А. Насоновой» РАМН, Москва
Евгений Львович Насонов
ФГБУ «Научно-исследовательский институт ревматологии им. акад. В.А. Насоновой» РАМН, Москва
Литература
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Рецензия
Для цитирования:
Асеева ЕА, Соловьев СК, Насонов ЕЛ. Генно-инженерные биологические препараты в терапии системной красной волчанки. Современная ревматология. 2013;7(3):33-40. https://doi.org/10.14412/1996-7012-2013-11
For citation:
Aseeva EA, Solovyev SK, Nasonov EL. Genetically engineered biological agents in therapy for systemic lupus erythematosus. Sovremennaya Revmatologiya=Modern Rheumatology Journal. 2013;7(3):33-40. (In Russ.) https://doi.org/10.14412/1996-7012-2013-11
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