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Современная ревматология

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Терапия синдрома фибромиалгии на современном этапе

https://doi.org/10.14412/1996-7012-2014-2-76-82

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Аннотация

В статье приводятся данные о патогенетически значимых параметрах, участвующих в восприятии боли при фибромиалгии (ФМ): повышенная чувствительность или плотность допаминовых D2-рецепторов, усиление болевого сигнала в связи с увеличением уровня субстанции Р и недостаточная его модификация, обусловленная низким уровнем серотонина, феномен аллодинии, психосоматический компонент.

Приведены новые классификационные критерии ФМ и оценка тяжести симптомов, входящих в эти критерии. Показано, как изменилась терапия боли при ФМ за последнее десятилетие: уменьшение использования периферических анальгетических средств, трициклических антидепрессантов, возрастание частоты назначения ингибиторов обратного захвата серотинина (дулоксетина, милнаципрана) и прегабалина. Продемонстрированы эффективность и удовлетворительная переносимость прегабалина при боли. Проведено сравнение эффективности и переносимости дулоксетина, милнаципрана и прегабалина по данным 17 рандомизированных контролируемых исследований. 

Об авторах

Н.В. Чичасова
ФГБУ «Научно-исследовательский институт ревматологии им В.А. Насоновой» РАМН, Москва, Россия
Россия


Е.В. Иголкина
ФГБУ «Научно-исследовательский институт ревматологии им В.А. Насоновой» РАМН, Москва, Россия
Россия


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Для цитирования:


Чичасова Н., Иголкина Е. Терапия синдрома фибромиалгии на современном этапе. Современная ревматология. 2014;8(2):76-82. https://doi.org/10.14412/1996-7012-2014-2-76-82

For citation:


Chichasova N., Igolkina E. Current therapy of fibromyalgia syndrome. Modern Rheumatology Journal. 2014;8(2):76-82. (In Russ.) https://doi.org/10.14412/1996-7012-2014-2-76-82

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ISSN 1996-7012 (Print)
ISSN 2310-158X (Online)