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Современная ревматология

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Ангиогенез при псориазе и псориатическом артрите: клеточные и гуморальные механизмы, роль в патогенезе и поиск перспективных мишеней терапии

https://doi.org/10.14412/1996-7012-2014-2-71-75

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Аннотация

Проанализированы современные представления о роли ангиогенеза в патогенезе псориаза и псориатического артрита (ПсА). Рассмотрены особенности клеточных и гуморальных реакций, приводящие к развитию пролиферации синовиальной оболочки и разрастанию в ней сосудов при данной патологии. Показано, что в прогрессировании процессов неоваскуляризации участвуют ряд медиаторов ангиогенеза, проангиогеннные цитокины, факторы роста, матриксные металлопротеиназы и др. Обращено внимание на роль фактора некроза опухоли α как важнейшей мишени таргетной терапии псориаза и ПсА, рассмотрены лекарственные средства, используемые или разрабатываемые для этой цели, блокирующие некоторые звенья ангиогенеза. 

Об авторе

Т.В. Коротаева
ФГБУ «Научно-исследовательский иститут ревматологии им. В.А. Насоновой» РАМН, Москва, Россия
Россия


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Для цитирования:


Коротаева Т. Ангиогенез при псориазе и псориатическом артрите: клеточные и гуморальные механизмы, роль в патогенезе и поиск перспективных мишеней терапии. Современная ревматология. 2014;8(2):71-75. https://doi.org/10.14412/1996-7012-2014-2-71-75

For citation:


Korotaeva T. Angiogenesis in patients with psoriasis and psoriatic arthritis: cell-mediated and humoral mechanisms, its role in pathogenesis, and searching for promising therapeutic targets. Modern Rheumatology Journal. 2014;8(2):71-75. (In Russ.) https://doi.org/10.14412/1996-7012-2014-2-71-75

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ISSN 1996-7012 (Print)
ISSN 2310-158X (Online)