Relationship between bone mineral density and immune inflammatory parameters in women with osteoporosis concurrent with coronary heart diseases
https://doi.org/10.14412/1996-7012-2014-3-41-44
Abstract
Low bone mineral density (BMD) is a risk factor of osteoporotic fractures. The RANKL–RANK–OPG system and some cytokines are known to play a role in the regulation of bone remodeling. Cytokines and osteoprotegerin (OPG) are able to affect the cardiovascular system. It is highly relevant to study the relationship between BMD and cytokine levels in patients with a concurrence of osteoporosis (OP) and coronary atherosclerosis.
Objective: to estimate the relationship between BMD and the level of cytokines and OPG in women having OP comorbid with coronary heart disease (CHD).
Subjects and methods. Sixty women (mean age 68.7±8.8 years) with OP comorbid with CHD (Group 1) were examined; a control group consisted of 38 patients (mean age 69.4±8.1 years) with isolated CHD (Group 2). BMD was measured in two regions: lumbar vertebrae (LI–IV) and proximal femur, by employing a DEXA densitometer (CHALLENGER, France). The serum levels of OPG, interleukin (IL) 1β, 4, 6, 8, 10, and tumor necrosis factor (TNF) α were determined by enzyme-linked immunosorbent assay (ELISA).
Results. The women with comorbidity were observed to have elevated IL6, 8, TNF-α, IL4, 10, and OPG levels. There was a negative correlation between IL1, TNF-α, and IL8 levels and vertebral BMD; OPG, IL4, 6, 8, and TNF-α concentrations were inversely related to femoral neck BMD. The independent factor of lower BMD was IL6 in the femoral neck and IL1 in the lumbar vertebrae. The findings suggest that there is a relationship between elevated cytokine levels and lower BMD in women having OP comorbid with CHD.
About the Authors
S. Yu. Tsarenok
Chita State Medical Academy, Chita, Russia
39A, Gorky St., Chita 672090
Russian Federation
Russian Federation
V. V. Gorbunov
Chita State Medical Academy, Chita, Russia
39A, Gorky St., Chita 672090
Russian Federation
Russian Federation
T. A. Aksenova
Chita State Medical Academy, Chita, Russia
39A, Gorky St., Chita 672090
Russian Federation
Russian Federation
References
1. IOF Word Congress on Osteoporosis and 10th European Congress of Clinical and Economic aspect of Osteoporosis and Osteoarthritis. IOF Word Congress. Osteoporosis Int. 2010;21 (Suppl 1):25–388.
2. Harvey N, Dennison EM, Cooper C. Osteoporosis: impact on health and economics. Nat Rev Rheumatol. 2010;6 (suppl. 1): 99–105. DOI: http://dx.doi.org/10.1038/ nrrheum.2009.260.
3. Rucci N. Molecular biology of bone remodeling. Clin Cases Miner Bone Metab. 2008;5(1):49–56.
4. Crockett JC, Rogers MJ, Coxon FP, et al. Bone remodeling at a glance. J Cell Sci. 2011;124(Pt 7):991–8. DOI: 10.1242/jcs.063032.
5. Sagalovsky S, Schö nert M. RANKLRANK-OPG system and bone remodeling: a new approach to the treatment of osteoporosis. Clin Exp Pathol. 2011;10(2):146–53.
6. Jorgensen NR. Cytokines and osteoporosis. Ugeskr Laeger. 1997;160(1):24–8.
7. McLeanRR Proinflammatory cytokines and osteoporosis. Curr Osteoporos Rep. 2009;7(4):134–9. DOI: http://dx.doi.org/10. 1007/s11914-009-0023-2.
8. Lee YM, Fujicado N, Manaka H, et al. IL-1 plays an impotent role in the bone metabolism under physiological conditions. Int Immunol. 2010;22(10):805–16. DOI: 10.1093/intimm/dxq431. Epub 2010 Aug 2.
9. Goswami J, Herdanzen-Santos N, Zuniga LA, Gaffen SL. A bone protective role for IL-17 receptor signaling in ovariectomy-indused bone loss. Eur J Immunol. 2009;39(10):2831–9. DOI: http://dx.doi.org/10.1002/eji.200939670.
10. Lubberts E, van den Bersselaar L, Oppers-Walgreen B, et al. IL-17 promotes bone erosion in murine collagen-indused arthritis through loss of the receptor activation of NF-kappa B ligand/osteoprotegerin balance. J Immunol. 2003;170(5):2655–62. DOI: http://dx.doi.org/10.4049/jimmunol. 170.5.2655.
11. Karouzakis E, Neidhart M, Gay RE, et al. Molecular and cellular basis of rheumatoid joint destraction. Immunol Lett. 2006;106(1):8–13. DOI: http://dx.doi.org/10.1016/j.imlet. 2006.04.011. Epub 2006 May 24.
12. Tanko LB, Christiansen C, Cox DA, et al. Relationship between osteoporosis and cardiovasculardisease in postmenopausal women. J Bone Miner Res. 2005;20(11):1912–20. DOI: http://dx.doi.org/10.1359/JBMR.050711.
13. Marcovitz PA, Tran HH, Franklin BA, et al. Usefulness of bone mineral density to predict significantcoronary artery disease. Am J Cardiol. 2005;96(8):1059–63. DOI: http://dx.doi.org/10.1016/j.amjcard.2005.06.034. Epub 2005 Aug 22.
14. Hak AE, Pols HA, van Hemert AM, et al. Progression of aortic calcification is associated withmetacarpal bone loss during menopause: a population-based longitudinal study. Arterioscler Thromb Vase Biol. 2000;20(8):1926–31. DOI: http://dx.doi.org/10.1161/01.ATV.20.8.1926.
15. Baumann H, Gauldie J. The acute phase response. Immunol Today. 1994;15(2):74–80. DOI: http://dx.doi.org/10.1016/0167-5699(94)90137-6.
16. Heinisch RH, Zanetti CR, Comin F, et al. Infflammatory cytokines predict one-year outcome of patient with acute coronary syndromes but not in stable angina. Eur Heart J. 2001;(22):518.
17. Ouchi Y, Akashita M, De Souza AC, et al. Age-related loss of bone mass and aortic/aortic valve calcification-reevaluation of recomended dietary allowance of calcium in the eldery. Ann NY Acad Sci. 1993;676:297–307. DOI: http://dx.doi. org/10.1111/j.1749-6632.1993.tb38743.x.
18. Sun T, Wang X, Liu Z, et al. Plasma concentrations of pro- and anti-inflammatory cytokines and outcome prediction in elderly hip fracture patients. Injury. 2011;42(7):707–13. DOI: http://dx.doi.org/10.1016/j.injury.2011. 01.010.
19. Inoue T, Komoda H, Nokana M, et al. Interleukin-8 as an independent predictor of long-term clinical outcome in patient with coronary artery disease. Int J Cardiol. 2008;124(3):319–25. DOI: http://dx.doi.org/10.1016/j.ijcard. 2007.02.012.
20. Kim CS, Park HS, Kawada T, et al. Circulating levels of MCP-1 and IL-8 are elevated in human obese subjects and associated with obesity-related parameters. Int J Obes (Lond). 2006;30(9):1347–55. DOI: http://dx.doi.org/10.1038/sj.ijo.0803259. Epub 2006 Mar 14.
21. Pestka S, Krause CD, Sarkar D, et al. IL-10 and related cytokines and receptors. Annu Rev Immunol. 2004;22:929–79. DOI: http://dx.doi.org/10.1146/annurev.immunol. 22.012703.104622.
22. Caidahl K, Ueland T, Aurrust P. Osteoprotegerin: a biomarker with many faces. Atherosclerosis Thrombosis Vasc Biol. 2010;30(9):1684–6. DOI: http://dx.doi.org/10.1161/ATVBА-HA.110.208843.
Review
For citations:
Tsarenok SY, Gorbunov VV, Aksenova TA. Relationship between bone mineral density and immune inflammatory parameters in women with osteoporosis concurrent with coronary heart diseases. Sovremennaya Revmatologiya=Modern Rheumatology Journal. 2014;8(3):41-44. (In Russ.) https://doi.org/10.14412/1996-7012-2014-3-41-44
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