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Современная ревматология

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Голимумаб в лечении псориатического артрита: эффективность и безопасность

https://doi.org/10.14412/1996-7012-2015-3-48-53

Аннотация

Фактор некроза опухоли a (ФНОa) занимает центральное место в патогенезе аутоиммунных воспалительных заболеваний опорно-двигательного аппарата. В настоящее время врачам доступен отдельный класс лекарственных препаратов, инигибиторов ФНОa (иФНОa), эффективных в отношении таких многокомпонентных по своим проявлениям заболеваний, как псориатический артрит (ПсА). Представлен обзор результатов клинических исследований иФНОa голимумаба (ГЛМ), человеческого моноклонального антитела к ФНОa. ГЛМ оказывает положительное влияние на все проявления ПсА: артрит, псориатическое поражение кожи и ногтей, дактилит, энтезит, качество жизни.

ГЛМ отличается удобным способом введения – стандартная доза составляет 50 мг в виде подкожных инъекций 1 раз в месяц, а также низкой иммунногенностью молекулы. Полученные к настоящему времени данные свидетельствуют о том, что ГЛМ является эффективным лекарственным средством с профилем безопасности, соответствующим таковому всего класса ингибиторов ФНОα.

Об авторах

Татьяна Викторовна Коротаева
ФГБНУ Научно-исследовательский институт ревматологии им. В.А. Насоновой
Россия
115522, Москва, Каширское шоссе, 34А


Е. Ю. Логинова
ФГБНУ Научно-исследовательский институт ревматологии им. В.А. Насоновой
Россия
115522, Москва, Каширское шоссе, 34А


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Для цитирования:


Коротаева Т.В., Логинова Е.Ю. Голимумаб в лечении псориатического артрита: эффективность и безопасность. Современная ревматология. 2015;9(3):48-53. https://doi.org/10.14412/1996-7012-2015-3-48-53

For citation:


Korotaeva T.V., Loginova E.Y. Golimumab in the treatment of psoriatic arthritis: efficacy and safety. Modern Rheumatology Journal. 2015;9(3):48-53. https://doi.org/10.14412/1996-7012-2015-3-48-53

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ISSN 1996-7012 (Print)
ISSN 2310-158X (Online)