Клеточно-молекулярные механизмы развития остеопороза: современные концепции и будущее направление терапии
https://doi.org/10.14412/1996-7012-2016-2-56-63
Аннотация
В обзоре литературы представлены современные взгляды на клеточно-молекулярные механизмы развития ремоделирования кости и патогенез остеопороза. Открытие цитокиновой системы RANKL-RANK-OPG и значительной роли катепсина К в процессе ремоделирования костной ткани способствовало значительному прогрессу в понимание механизмов развития остеопороза и позволило разработать препараты нового поколения – деносумаб, полностью человеческое моноклональное антитело к RANKL (receptor activator nucleus factor kappa B ligand), и ингибитор катепсина К оданакатиб, угнетающие процесс резорбции костной ткани.
Об авторах
А. Т. Долженко
Институт молекулярной медицины, Университет им. Мартина Лютера Галле-Виттенберг, Германия
Россия
Россия
С. Сагаловски
Отдел ортопедии клиники Медиан, Бад Лаузик, Германия
Россия
Россия
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Рецензия
Для цитирования:
Долженко А.Т., Сагаловски С. Клеточно-молекулярные механизмы развития остеопороза: современные концепции и будущее направление терапии. Современная ревматология. 2016;10(2):56-63. https://doi.org/10.14412/1996-7012-2016-2-56-63
For citation:
Dolzhenko A.T., Sagalovsky S. Cellular and molecular mechanisms of osteoporosis: current concepts and future direction treatment. Modern Rheumatology Journal. 2016;10(2):56-63. https://doi.org/10.14412/1996-7012-2016-2-56-63
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