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Современная ревматология

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Позитивность по антителам к рибонуклеопротеину при ревматических заболеваниях: фокус на системную склеродермию

https://doi.org/10.14412/1996-7012-2017-4-48-55

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Аннотация

Обзор посвящен проблеме антителообразования при системной склеродермии (ССД), с акцентом на антитела к рибонуклеопротеину (РНП): частоте встречаемости, структуре, клиническим ассоциациям. ССД – прогрессирующее полисиндромное заболевание с характерным поражением кожи, опорно-двигательного аппарата, внутренних органов (сердца, легких, пищеварительного тракта, почек) и распространенными вазоспастическими нарушениями по типу синдрома Рейно, в основе которых лежат процессы дезорганизации соединительной ткани с преобладанием фиброзно-склеротических изменений и сосудистой патологии по типу своеобразного облитерирующего эндартериита. Наличие антител к различным аутоантигенам – характерная черта ССД. Среди пациентов, удовлетворяющих классификационным критериям ССД, имеется подгруппа больных, у которых не выявляются специфические для ССД антиядерные антитела, но присутствуют антитела к растворимым ядерным аутоантигенам, а именно – антителам к РНП. Данный тип аутоантител (аутоАТ) описан при различных системных заболеваниях соединительной ткани: системной красной волчанке, дерматомиозите и полимиозите, ССД. Частота выявления антител к РНП при ССД варьирует в разных этнических группах в пределах 5–30%. Кроме того, позитивность по антителам к РНП является характерной чертой смешанного заболевания соединительной ткани. На сегодняшний день представляет интерес более детальное изучение больных ССД, позитивных по антителам к U1-РНП, с возможностью выделения нового субтипа ССД, а также сравнения и поиска отличий носителей антител к U1-РНП от других хорошо описанных фенотипов ССД. Данная проблема представляется актуальной, учитывая активно разрабатываемый в ревматологии персонифицированный подход к курации больных.

 

Об авторах

Р. У. Шаяхметова
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой», Москва
Россия


Л. П. Ананьева
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой», Москва
Россия


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Для цитирования:


Шаяхметова Р.У., Ананьева Л.П. Позитивность по антителам к рибонуклеопротеину при ревматических заболеваниях: фокус на системную склеродермию. Современная ревматология. 2017;11(4):48-55. https://doi.org/10.14412/1996-7012-2017-4-48-55

For citation:


Shayakhmetova R.U., Ananyeva L.P. Positivity for antiribonucleoprotein antibodies in rheumatic diseases: focus on scleroderma systematica. Modern Rheumatology Journal. 2017;11(4):48-55. (In Russ.) https://doi.org/10.14412/1996-7012-2017-4-48-55

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ISSN 1996-7012 (Print)
ISSN 2310-158X (Online)