Дактилит при псориатическом артрите : особенности клинических проявлений, диагностика, иммунопатогенез и лечение
Аннотация
При обнаружении дактилита у больного псориатическим артритом (ПсА) необходимо как можно раньше назначить активное лечение, поскольку в отсутствие терапии наблюдается прогрессирование заболевания вплоть до эрозирования суставов и развития функциональных нарушений. В статье рассмотрены клинические признаки и диагностика ПсА, отмечена важность дифференциальной диагностики по этому признаку с другими воспалительными заболеваниями суставов. Указана необходимость выработки единых подходов к объективной оценке тяжести дактилита. Подробно описаны иммунопатогенез и основные направления его лечения, в том числе с использованием генно-инженерных биологических препаратов (ГИБП). Приведены данные клинических исследований, в которых оценивалась эффективность лечения дактилита и установлено, что использование ГИБП в большинстве случаев способствует существенному уменьшению не только выраженности его клинических признаков, но и сопутствующего отека костного мозга. Отмечено, что разработка новых патогенетических методов лечения, таргетных в отношении ряда установленных к настоящему времени биологически активных молекул, которые играют важную роль в патогенезе дактилита, будет способствовать повышению эффективности лечения больных ПсА.
Ключевые слова
Об авторах
Т. В. Коротаева
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия
115522, Москва, Каширское шоссе, 34А
Россия
115522, Москва, Каширское шоссе, 34А
Е. Ю. Логинова
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия
115522, Москва, Каширское шоссе, 34А
Россия
115522, Москва, Каширское шоссе, 34А
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Для цитирования:
Коротаева Т.В., Логинова Е.Ю. Дактилит при псориатическом артрите : особенности клинических проявлений, диагностика, иммунопатогенез и лечение. Современная ревматология. 2018;12(1):5-12. https://doi.org/10.14412/1996-7012-2018-1-5-12
For citation:
Korotaeva T.V., Loginova E.Y. Dactylitis in psoriatic arthritis: clinical features, diagnosis, immunopathogenesis, and treatment. Modern Rheumatology Journal. 2018;12(1):5-12. (In Russ.) https://doi.org/10.14412/1996-7012-2018-1-5-12
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