Дактилит при псориатическом артрите : особенности клинических проявлений, диагностика, иммунопатогенез и лечение

При обнаружении дактилита у больного псориатическим артритом (ПсА) необходимо как можно раньше назначить активное лечение, поскольку в отсутствие терапии наблюдается  прогрессирование заболевания вплоть до эрозирования суставов и развития функциональных нарушений. В статье рассмотрены клинические признаки и  диагностика ПсА, отмечена важность дифференциальной диагностики по этому признаку с  другими воспалительными заболеваниями суставов. Указана необходимость выработки  единых подходов к объективной оценке тяжести дактилита. Подробно описаны  иммунопатогенез и основные направления его лечения, в том числе с использованием  генно-инженерных биологических препаратов (ГИБП). Приведены данные клинических  исследований, в которых оценивалась эффективность лечения дактилита и установлено, что использование ГИБП в большинстве случаев способствует существенному уменьшению не  только выраженности его клинических признаков, но и сопутствующего отека костного  мозга. Отмечено, что разработка новых патогенетических методов лечения, таргетных в отношении ряда установленных к настоящему времени биологически активных молекул,  которые играют важную роль в патогенезе дактилита, будет способствовать повышению  эффективности лечения больных ПсА.

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