The place of a phosphodiesterase 4 inhibitor in the treatment strategy for psoriatic arthritis
https://doi.org/10.14412/1996-7012-2018-1-41-46
Abstract
Psoriatic arthritis (PsA) is a chronic inflammatory disease of the joints, spine, and entheses, which is associated with psoriasis. The pathological process is localized mainly in the tissues of the locomotor system and leads to the development of erosive arthritis and intra-articular osteolysis. PsA occurs in 5–7% of patients with moderate psoriasis. Despite advances in the treatment of psoriasis and PsA with diseasemodifying antirheumatic drugs (DMARDs) and biological agents (BAs), the problems associated with immunogenicity, infectious complications, and secondary inefficiency have not been fully solved. These factors have motivated the search for novel targeted synthetic drugs (signaling pathway inhibitors). This group of drugs includes apremilast, a phosphodiesterase 4 inhibitor. Recent data of controlled studies suggest that the drug is effective and safe in treating psoriasis and PsA. Prospects for the use of apremilast in PsA are associated with the possibility to use the drug in patients because of the inefficacy of DMARDs or BAs and with the ability to maintain long-term (more than 3-year) remission and to reduce the manifestations of enthesitis and dactylitis.
About the Authors
V. I. Mazurov
I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia
Russian Federation
41, Kirochnaya St., Saint Petersburg 191015
Russian Federation
41, Kirochnaya St., Saint Petersburg 191015
E. A. Trofimov
I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia
Russian Federation
41, Kirochnaya St., Saint Petersburg 191015
Russian Federation
41, Kirochnaya St., Saint Petersburg 191015
I. Z. Gaydukova
I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia
Russian Federation
41, Kirochnaya St., Saint Petersburg 191015
Russian Federation
41, Kirochnaya St., Saint Petersburg 191015
References
1. Мазуров ВИ. Болезни суставов. Руководство для врачей. Санкт-Петербург: СпецЛит; 2008. 408 c. [Mazurov VI. Bolezni sustavov. Rukovodstvo dlya vrachei [Diseases of the joints. A guide for physicians]. Saint- Petersburg: SpetsLit; 2008. 408 p.]
2. Parisi R, Symmons D P, Griffiths C E, Ashcroft DM. Global epidemiology of psoriasis: A systematic review of incidence and prevalence. J Invest Dermatol. 2013 Feb;133(2): 377-85. doi: 10.1038/jid.2012.339. Epub 2012 Sep 27.
3. Eder L, Cohen AD, Feldhamer I, et al. The epidemiology of psoriatic arthritis in Israel – a population-based study. Arthritis Res Ther. 2018 Jan 2;20(1):3. doi: 10.1186/s13075-017-1497-4.
4. Sewerin P, Hoyer A, Schneider M, et al. Inconsistency between Danish incidence and prevalence data about psoriatic arthritis (PsA). Ann Rheum Dis. 2018 Jan 2. pii: annrheumdis-2017-212817. doi: 10.1136/annrheumdis-2017-212817. [Epub ahead of print]
5. Псориатический артрит. https://psoriazov.net/vidy-psoriaza/klassifikaciya-psoriaza.html [Psoriatic arthritis. https://psoriazov.net/vidy-psoriaza/klassifikaciya-psoriaza.html]
6. Hawkes JE, Chan TC, Krueger JG. Psoriasis pathogenesis and the development of novel targeted immune therapies. J Allergy Clin Immunol. 2017 Sep;140(3):645-653. doi: 10.1016/j.jaci.2017.07.004.
7. Paine A, Ritchlin C. Altered Bone Remodeling in Psoriatic Disease: New Insights and Future Directions. Calcif Tissue Int. 2018 Jan 12. doi: 10.1007/s00223-017-0380-2. [Epub ahead of print].
8. Eyre S, Orozco G, Worthington J. The genetics revolution in rheumatology: large scale genomic arrays and genetic mapping. Nat Rev Rheumatol. 2017 Jul;13(7):421-432. doi: 10.1038/nrrheum.2017.80. Epub 2017 Jun 1.
9. Yago T, Nanke Y, Kawamoto M, et al. IL-23 and Th17 Disease in Inflammatory Arthritis. J Clin Med. 2017 Aug 29;6(9). pii: E81. doi: 10.3390/jcm6090081.
10. Мазуров ВИ, Трофимов ЕА. Ревматология. Фармакотерапия без ошибок: руководство для врачей. Москва: Е-ното; 2017. 528 с. [Mazurov VI, Trofimov EA. Revmatologiya. Farmakoterapiya bez oshibok: rukovodstvo dlya vrachei [Rheumatology. Pharmacotherapy without errors: a guide for physicians]. Moscow: E-noto; 2017. 528 p.].
11. Alwan W, Nestle FO. Pathogenesis and treatment of psoriasis: Exploiting pathophysiological pathways for precision medicine. Clin Exp Rheumatol. 2015 Sep-Oct;33(5 Suppl 93): S2-6. Epub 2015 Oct 15
12. Молочков ВА, Бадокин ВВ, Альбанова ВИ. Псориаз и псориатический артрит. Москва: Товарищество научных изданий КМК; 2007. 300 с. [Molochkov VA, Badokin VV, Al'banova VI. Psoriaz i psoriaticheskii artrit [Psoriasis and psoriatic arthritis]. Moscow: Tovarishchestvo nauchnykh izdanii KMK; 2007. 300 p.]
13. Федеральные клинические рекомендации по ведению больных псориазом. http://mzdrav.rk.gov.ru/file/Psoriaz_05052014_Klinicheskie_rekomendacii.pdf. [Federal clinical guidelines for the management of psoriasis patients. http://mzdrav.rk.gov.ru/file/Psoriaz_05052014_Klinicheskie_rekomendacii.pdf]
14. Федеральные клинические рекомендации по ведению больных псориатическим артритом. http://www.ismos.ru/guidelines/doc/psoriaticheskij_artrit.pdf. [Federal clinical guidelines for the management of patients with psoriatic arthritis. http://www.ismos.ru/guidelines/doc/psoriaticheskij_artrit.pdf]
15. Coates LC, Kavanaugh A, Mease PJ, et al. Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA): Treatment Recommendations for Psoriatic Arthritis 2015. Arthritis Rheumatol. 2016 May; 68(5):1060-71. doi: 10.1002/art.39573. Epub 2016 Mar 23
16. Gosses L, Smolen JS, Ramiro S, et al. European Leaque Against Rheumatism (EULAR) recommendations for the management of psoriatic arthritis with pharmacological therapies: 2015 update. Ann Rheum Dis. 2016 Mar;75(3):499-510. doi: 10.1136/annrheumdis-2015-208337. Epub 2015 Dec 7.
17. Sakkas LI, Mavropoulos A, Bogdanos DP. Phosphodiesterase 4 Inhibitors in Immunemediated Diseases: Mode of Action, Clinical Applications, Current and Future Perspectives. Curr Med Chem. 2017;24(28):3054-3067. doi: 10.2174/0929867324666170530093902.
18. Gladman DD, Kavanaugh A, Gomez-Reino JJ, et al. Apremilast treatment and long-term (up to 156 weeks) improvements in dactylitis and enthesitis in patients with psoriatic arthritis: analysis of a large database of the phase III clinical development program. Ann Rheum Dis. 2017;76(suppl2):942.
19. Гайдукова ИЗ, Ребров АП, Апаркина АВ, Хондкарян ЭВ. Концентрация интерлейкина-17α остается стабильно высокой у больных анкилозирующим спондилитом, получающих ингибиторы фактора некроза опухоли α в течение года. Терапевтический архив. 2017;89(4):80-5. [Gaidukova IZ, Rebrov AP, Aparkina AV, Khondkaryan EV. The concentration of interleukin-17α remains high in patients with ankylosing spondylitis receiving inhibitors of tumor necrosis factor α in the course of the year. Terapevticheskii arkhiv. 2017;89(4):80-5. (In Russ.)].
20. Armstrong A, Levi E. Real-world clinical experience with apremilast in a large us retrospective cohort study of patients with moderate to severe plaque psoriasis. J Drugs Dermatol. 2017 Dec 1;16(12):1240-1245.
21. Dattola A, Del Duca E, Saraceno R, et al. Safety evaluation of apremilast for the treatment of psoriasis. Expert Opin Drug Saf. 2017; Mar;16(3):381-385. doi: 10.1080/14740338.2017.1288714. Epub 2017 Feb 7.
22. Kavanaugh A, Gladman DD, Gomez-Reino JJ, et al. Durability of apremilast response in patients with psoriatic arthritis: long-term (208-week) results from the PALACE 1 trial. Ann Rheum Dis. 2017; 76(suppl2):936.
23. Reich K, Gooderham M, Bewley A, et al. Safety and efficacy of apremilast through 104 weeks in patients with moderate to severe psoriasis who continued on apremilast or switched from etanercept treatment: findings from the LIBERATE study. J Eur Acad Dermatol Venereol. 2017 Dec 8. doi: 10.1111/jdv.14738. [Epub ahead of print]
24. Armstrong AW, Robertson AD, Wu J, et al. Undertreatment, treatment trends, and treatment dissatisfaction among patients with psoriasis and psoriatic arthritis in the United States: Findings from the National Psoriasis Foundation surveys, 2003–2011. JAMA Dermatol. 2013 Oct; 149(10):1180-5. doi: 10.1001/jamadermatol.2013.5264.
25. Kavanaugh A, Mease PJ, Gomez-Reino JJ, et al. Longterm (52-week) Results of a Phase III Randomized, Controlled Trial of Apremilast in Patients with Psoriatic Arthritis. J Rheumatol. 2015 Mar;42(3):479-88. doi: 10.3899/jrheum.140647. Epub 2015 Jan 15.
26. Kavanaugh A, Mease PJ, Gomez-Reino JJ, et al. Treatment of psoriatic arthritis in a phase 3 randomised, placebo-controlled trial with apremilast, an oral phosphodiesterase 4 inhibitor. Ann Rheum Dis. 2014 Jun;73(6):1020-6. doi: 10.1136/annrheumdis-2013-205056. Epub 2014 Mar 4.
27. Papp K, Reich K, Leonardi CL, et al. Apremilast, an oral phosphodiesterase 4 (PDE4) inhibitor, in patients with moderate to severe plaque psoriasis: Results of a phase III, randomized, controlled trial (efficacy and safety trial evaluating the effects of apremilast in psoriasis [ESTEEM] 1). J Am Acad Dermatol. 2015 Jul;73(1):37-49. doi: 10.1016/j.jaad.2015.03.049.
28. Paul C, Cather J, Gooderham M, et al. Efficacy and safety of apremilast, an oral phosphodiesterase 4 inhibitor, in patients with moderate to severe plaque psoriasis over 52 weeks: A phase III, radomized, controlled trial (ESTEEM 2). Br J Dermatol. 2015 Dec; 173(6):1387-99. doi: 10.1111/bjd.14164. Epub 2015 Nov 7.
29. Crowley J, Thaci D, Joly P, et al. Longterm safety and tolerability of apremilast in patients with psoriasis: Pooled safety analysis for ≥156 weeks from 2 phase 3, randomized, controlled trials (ESTEEM 1 and 2). J Am Acad Dermatol. 2017 Aug;77(2):310-317.e1. doi: 10.1016/j.jaad.2017.01.052. Epub 2017 Apr 14.
30. Bissonnette R, Pariser DM, Wasel NR, et al. Apremilast, an oral phosphodiesterase-4 inhibitor, in the treatment of palmoplantar psoriasis: Results of a pooled analysis from phase II PSOR-005 and phase III Efficacy and Safety Trial Evaluating the Effects of Apremilast in Psoriasis (ESTEEM) clinical trials in patients with moderate to severe psoriasis. J Am Acad Dermatol. 2016 Jul;75(1): 99-105. doi: 10.1016/j.jaad.2016.02.1164. Epub 2016 Mar 24.
Review
For citations:
Mazurov VI, Trofimov EA, Gaydukova IZ. The place of a phosphodiesterase 4 inhibitor in the treatment strategy for psoriatic arthritis. Sovremennaya Revmatologiya=Modern Rheumatology Journal. 2018;12(1):41-46. (In Russ.) https://doi.org/10.14412/1996-7012-2018-1-41-46
Views:
850
Email this article 