Регуляторы роста паннуса при ревматоидном артрите, являющиеся потенциальными мишенями биологической терапии
Аннотация
Основной целью лечения ревматоидного артрита (РА) является подавление воспаления с помощью базисной и симптоматической терапии. При этом указанная стратегия значимо не останавливает деструкцию сустава, ведущую к инвалидизации пациентов. В обзоре представлен анализ публикаций, посвященных поиску регуляторов межклеточного взаимодействия среди основных эффекторных клеток паннуса – фибробластоподобных синовиоцитов (ФПС). Представлены оценка влияния факторов агрессии ФПС на инвазивное «поведение» паннуса, возможность их прицельной дезактивации в рамках биологической терапии, а также предварительные результаты подобного лечения на примерах животных моделей. Показано, что наиболее перспективными мишенями биологической терапии могут являться молекулы адгезии ФПС: трансмембранный рецептор кадгерин 11, интегрины α5/β1, VCAM1, ICAM1, активно участвующие в процессах прикрепления ФПС к поверхности хряща и активирующие выработку ими цитокинов, факторов роста и агрессии.
Об авторах
А. С. Михайлова
ФГБОУ ВО «Уральский государственный медицинский университет» Минздрава России
Россия
620028, Екатеринбург, ул. Репина, 3
Россия
620028, Екатеринбург, ул. Репина, 3
О. М. Лесняк
ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава России
Россия
191015, Санкт-Петербург, ул. Кирочная, 41
Россия
191015, Санкт-Петербург, ул. Кирочная, 41
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Для цитирования:
Михайлова А.С., Лесняк О.М. Регуляторы роста паннуса при ревматоидном артрите, являющиеся потенциальными мишенями биологической терапии. Современная ревматология. 2018;12(1):55-59. https://doi.org/10.14412/1996-7012-2018-1-55-59
For citation:
Mikhaylova A.S., Lesnyak O.M. Pannus growth regulators as potential targets for biological therapy in rheumatoid arthritis. Modern Rheumatology Journal. 2018;12(1):55-59. (In Russ.) https://doi.org/10.14412/1996-7012-2018-1-55-59
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