Хроническая болезнь почек: роль гиперурикемии и возможности урат-снижающей терапии
https://doi.org/10.14412/1996-7012-2018-1-60-65
Аннотация
Результаты многочисленных эпидемиологических исследований позволяют предполагать взаимосвязь хронической болезни почек (ХБП) и асимптоматической гиперурикемии, при этом появляется все больше свидетельств того, что повышенный уровень мочевой кислоты (МК) является причиной повреждения почек. Среди возможных механизмов развития ХБП при гиперурикемии называют иммунное воспаление, как опосредованное кристаллизацией МК, так и не зависящее от кристаллообразования, влияние на активность ренин- ангиотензин-альдостероновой системы. Имеющиеся в настоящий момент оптимистичные данные об эффективности медикаментозной коррекции гиперурикемии на разных стадиях ХБП, обоснованы прежде всего длительным приемом ингибиторов ксантиноксидазы (аллопуринол, фебуксостат) и позволяют рассматривать урат-снижающую терапию как потенциально нефропротективную. В то же время для их подтверждения необходимы дальнейшие крупные рандомизированные контролируемые исследования.
Об авторе
М. С. Елисеев
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия
115522, Москва, Каширское шоссе, 34А
Россия
115522, Москва, Каширское шоссе, 34А
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Рецензия
Для цитирования:
Елисеев МС. Хроническая болезнь почек: роль гиперурикемии и возможности урат-снижающей терапии. Современная ревматология. 2018;12(1):60-65. https://doi.org/10.14412/1996-7012-2018-1-60-65
For citation:
Eliseev MS. Chronic kidney disease: the role of hyperuricemia and the possibility of urate-lowering therapy. Sovremennaya Revmatologiya=Modern Rheumatology Journal. 2018;12(1):60-65. (In Russ.) https://doi.org/10.14412/1996-7012-2018-1-60-65
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