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Современная ревматология

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Актуальная стратегия лечения подагрического артрита

https://doi.org/10.14412/1996-7012-2018-3-70-75

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Аннотация

Фебуксостат – непуриновый селективный ингибитор изоформ ксантиноксидоредуктазы (КОР), действие которого направлено на снижение уровня мочевой кислоты в сыворотке крови. Фебуксостат – более мощный ингибитор КОР, чем аллопуринол, что подтверждается достижением целевого уровня МК при лечении фебуксостатом чаще, чем при приеме аллопуринола, особенно у пациентов с высокой концентрацией уратов в сыворотке крови. Фармакокинетические свойства фебуксостата не зависят от почечного клиренса, что отличает его от аллопуринола и может быть преимуществом для пациентов с хроническими заболеваниями почек. В ряде исследований проводится дальнейшая оценка безопасности фебуксостата для сердечно-сосудистой системы и его возможного позитивного действия на сохранение функции почек. Важным является и то, что у пожилых пациентов не требуется коррекции дозы фебуксоcтата.

Об авторах

М. С. Петрова
ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава России
Россия

Марианна Семеновна Петрова

191015, Санкт-Петербург, ул. Кирочная, 41



М. М. Мусийчук
ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава России
Россия

191015, Санкт-Петербург, ул. Кирочная, 41



В. И. Мазуров
ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава России
Россия

191015, Санкт-Петербург, ул. Кирочная, 41



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Для цитирования:


Петрова М.С., Мусийчук М.М., Мазуров В.И. Актуальная стратегия лечения подагрического артрита. Современная ревматология. 2018;12(3):70-75. https://doi.org/10.14412/1996-7012-2018-3-70-75

For citation:


Petrova M.S., Musiychuk М.M., Mazurov V.I. The current treatment strategy for gouty arthritis. Modern Rheumatology Journal. 2018;12(3):70-75. (In Russ.) https://doi.org/10.14412/1996-7012-2018-3-70-75

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ISSN 1996-7012 (Print)
ISSN 2310-158X (Online)