Особенности Т- регуляторных клеток у больных системной красной волчанкой
Аннотация
Т-регуляторные (Т-рег) клетки – субпопуляция CD4+ лимфоцитов, поддерживающая аутотолерантность организма путем подавления активности аутореактивных лимфоцитов. Существует гипотеза, что дефекты функций или снижение количества Т-рег-клеток лежат в основе патогенеза ряда аутоиммунных заболеваний. В статье рассмотрены основные особенности фенотипа Т-рег-клеток. Обсуждаются количество Т-рег-клеток как в периферической крови, так и в пораженных органах при системной красной волчанке, а также динамика уровня и функциональных способностей различных субпопуляций Т-рег-клеток на фоне иммуносупрессивной терапии. Кроме того, представлены различные подходы к использованию Т-рег-лимфоцитов в терапии аутоиммунных заболеваний.
Об авторах
А. В. Торгашина
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой».
Россия
Россия
Анна Васильевна Торгашина.
115522, Москва, Каширское шоссе, 34А.
С. К. Соловьев
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой».
Россия
115522, Москва, Каширское шоссе, 34А.
Россия
115522, Москва, Каширское шоссе, 34А.
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Рецензия
Для цитирования:
Торгашина А.В., Соловьев С.К. Особенности Т- регуляторных клеток у больных системной красной волчанкой. Современная ревматология. 2018;12(4):9-15. https://doi.org/10.14412/1996-7012-2018-4-9-15
For citation:
Torgashina A.V., Solovyev S.К. Specific features of regulatory T cells in patients with systemic lupus erythematosus. Modern Rheumatology Journal. 2018;12(4):9-15. (In Russ.) https://doi.org/10.14412/1996-7012-2018-4-9-15
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