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Современная ревматология

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Стратификация больных и выбор терапии на основании профилей экспрессии генов в крови при ревматоидном артрите

https://doi.org/10.14412/1996-7012-2018-4-16-22

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Аннотация

Ревматоидный артрит (РА) – хроническое воспалительное заболевание неизвестной этиологии, при котором повреждаются разные участки иммунной системы и другие ткани, а также происходит деструкция суставов. Современные способы терапии направлены на подавление воспаления и снижение уровня боли, однако они не влияют на патофизиологические и биохимические механизмы, участвующие в разрушении сустава. Более того, больные РА представляют собой исключительно гетерогенную группу, поэтому не все они одинаково отвечают на лечение. В связи с этим необходима персонифицированная терапия. Однако в настоящее время оценка больного, включающая клинические, иммунологические и радиологические показатели, не позволяет предсказать ответ на антиревматическое лечение приблизительно в половине случаев. Тем не менее исследования последних лет свидетельствуют о том, что стратификация больных в соответствии с уровнем провоспалительных генов в крови способна помочь прогнозировать ответ на антиревматическую терапию.

Об авторах

E. В. Четина
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой».
Россия

Елена Васильевна Четина.

115522, Москва, Каширское шоссе, 34А.



Г. А. Маркова
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой».
Россия
115522, Москва, Каширское шоссе, 34А.


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Для цитирования:


Четина E.В., Маркова Г.А. Стратификация больных и выбор терапии на основании профилей экспрессии генов в крови при ревматоидном артрите. Современная ревматология. 2018;12(4):16-22. https://doi.org/10.14412/1996-7012-2018-4-16-22

For citation:


Chetina E.V., Markova G.A. Patient stratification and choice of therapy based on blood gene expression profiles in rheumatoid arthritis. Modern Rheumatology Journal. 2018;12(4):16-22. (In Russ.) https://doi.org/10.14412/1996-7012-2018-4-16-22

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