Drug-induced lupus
https://doi.org/10.14412/1996-7012-2018-4-32-41
Abstract
Drug-induced lupus (DIL) is an autoimmune phenomenon that has similar clinical and laboratory manifestations with idiopathic systemic lupus erythematosus (SLE). About 100 drugs are now known to be associated with the development of DIL. Its diagnosis is verified in the presence of a chronological relationship between the long-term administration of drugs and the mandatory presence of one clinical and one laboratory diagnostic criteria for SLE.
The paper deals with the etiology, pathogenesis, and differential diagnosis of DIL. It presents a spectrum of drugs that can cause DIL and considers the features of its different forms.
Based on the recent data available in the literature, the authors analyze the occurrence of autoimmune responses due to the useof biologic agents (BAs), primarily tumor necrosis factor-αinhibitors. Therapeutic approaches for DIL are discussed. Recommendations are given for screening the patients in the use of BAs. Clinical examples are provided.
About the Authors
N. G. Klyukvina
V.A. Nasonova Research Institute of Rheumatology.
Russian Federation
Russian Federation
Natalia Gennadyevna Klyukvina.
34A, Kashirskoe Shosse, Moscow 115522.
V. M. Gunchikova
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia.
Russian Federation
2, Bolshaya Pirogovskaya St., Build. 4, Moscow 119991.
Russian Federation
2, Bolshaya Pirogovskaya St., Build. 4, Moscow 119991.
A. M. Novikova
V.A. Nasonova Research Institute of Rheumatology.
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522.
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522.
References
1. Nasonov EL. New possibilities of pharmacotherapy for immunoinflammatory rheumatic diseases: a focus on inhibitors of interleukin-17. Nauchno-prakticheskaya revmatologiya = Rheumatology Science and Practice. 2017;55(1):68-86. (In Russ.). doi: 10.14412/1995-4484-2017-68-86
2. Nasonov EL. Pharmacotherapy for rheumatoid arthritis: new strategy, new targets. Nauchno-prakticheskaya revmatologiya = Rheumatology Science and Practice. 2017;55(4):409-19. (In Russ.). doi: 10.14412/1995-4484-2017-409-419
3. Vasoo S. Drug-induced lupus: an update. Lupus. 2006;15(11):757-61.
4. Vedove CD, Giglio MD, Schena D, Girolomoni G. Drug-induced lupus erythematosus.Arch Dermatol Res.2009 Jan;301(1):99-105. doi: 10.1007/s00403-008-0895-5. Epub 2008 Sep 17.
5. Hoffman BJ. Sensitivity of sulfadiazine resembling acute disseminated lupus erythematosus. Arch Dermatol Syph.1945;51:190-2.
6. Gold S. Role of sulphonamides and penicillin in the pathogenesis in systemic lupus erythematosus. Lancet. 1951 Feb 3;1(6649): 268-72.
7. Honey M. SLE presenting with sulphonamide hypersensitivity. Br Med J. 1956 Jun 2;1(4978):1272-5.
8. Morrow JD, Schroeder HA, Perry HM. Studies on the control of hypertension by Hyphex: II. Toxic reactions and side effects. Circulation. 1953 Dec;8(6):829-39.
9. Beernink DH, Miller JJ. Anticonvulsantinduced antinuclear antibodies and lupus-like disease in children. J Pediatr. 1973 Jan;82(1): 113-7.
10. Sarzi-Puttini P, Atzeni F, Capsoni F, et al. Drug-induced lupus erythematosus. Autoimmunity. 2005 Nov;38(7):507-18.
11. Perry HM, Schroeder HA. Syndrome simulating collagen disease caused by hydralazine (Apresoline). J Am Med Assoc. 1954 Feb 20;154(8):670-3.
12. Ghose MK. Pericardial tamponade. A presenting manifestation of procainamideinduced lupus erythematosus. Am J Med. 1975 Apr;58(4):581-5.
13. Khattak FH, Morris IM, Mattingly PC. Sulphasalazine-induced systemic lupus erythematosus in a patient with rheumatoid arthritis. Br J Rheumatol.1996 Jan;35(1):104.
14. Gordon MM, Porter DR, Capell HA. Does sulphasalazine cause druginduced systemic lupus erythematosus? No effect evident in a prospective randomized trial of 200 rheumatoid arthritis patients treated with either sulphasalazine or auranofin over five years. Ann Rheum Dis. 1999 May;58(5):288-90.
15. Mongey AB, Hess EV. Drug-Induced Disease. In: Lahita RD, editor. Systemic lupus erythematosus. 5th Edition. Elsevier; 2011.P. 599-628.
16. Elkayam O, Yaron M, Caspi D. Minocycline-induced autoimmune syndromes: an overview.Semin Arthritis Rheum. 1999 Jun;28(6):392-7.
17. Spiera RF, Bermman RS, Werner AJ, Spiera H. Ticlopidine-induced lupus: A report of 4 cases.Arch Intern Med. 2002 Oct 28;162(19):2240-3.
18. Atzeni F, Marrazza MG, Sarzi-Puttini P, Carrabba M. Drug-induced lupus erythematosus. Reumatismo. 2003;55(3):147-54.
19. Speirs C, Chapel H, Fielder AL, et al. Complement system protein C4 and susceptibility to hydralazine-induced systemic lupus erythematosus. Lancet. 1989 Apr 29;1(8644): 922-4.
20. Yung RL, Richardson BC. Drug-Induced lupus mechanisms. In: Lahita RD, editor. Systemic lupus erythematosus. 5th Edition. Elsevier; 2011.P. 385-404.
21. Rubin RL. Drug-induced lupus. Toxicology. 2005 Apr 15;209(2):135-47.
22. Uetrecht J. Current trends in druginduced autoimmunity. Toxicology. 1997 Apr 11;119(1):37-43.
23. Williams DP, Pirmohamed M, Naisbitt DJ, et al. Induction of metabolismdependent and independent neutrophil apoptosis by clozapine.Mol Pharmacol. 2000 Jul; 58(1):207-16.
24. Kretz-Rommel A, Rubin RL. Disruption of positive selection of thymocytes causing autoimmunity. Nat Med.2000 Mar;6(3):298-305.
25. Yung RL, Richardson BS. Drug-induced lupus. Rheum Dis Clin N Am. 1994;20:60-86. 26. Vivino FB, Schumacher HR Jr. Synovial fluid characteristics and the lupus erythematosus cell phenomenon in drug induced lupus. Arthritis Rheum.1989 May; 32(5):560-8.
26. Siddiqui MA, Khan IA. Isoniazidinduced lupus erythematosus presenting with cardiac tamponade. Am J Ther.2002 Mar-Apr;9(2):163-5.
27. Graziadei IW, Obermoser GE, Sepp NT, et al. Drug induced lupus like syndrome associated with severe autoimmune hepatitis. Lupus. 2003;12(5):409-12.
28. Callen JP. Drug-induced cutaneous lupus erythematosus, a distinct syndrome that is frequently under-recognised. J Am Acad Dermatol. 2001 Aug;45(2):315-6.
29. Ioannidis JI, Karassa FB, Druyls E. Biologic agents in rheumatology: unmet issues after 200 trials and $200 billion sales. Nat Rev Rheumatol. 2013;11:665-673. doi: 10.1038/nrrheum.2013.134.
30. Porfyridis I, Kalomenidis I, Psallidas I, et al. Etanercept-induced pleuropericardial lupus-like syndrome. Eur Respir J.2009 Apr;33(4):939-41. doi: 10.1183/09031936.00182308.
31. Choi HK, Merkel PA, Walker AM, Niles JL. Drug-associated antineutrophil cytoplasmic antibody-positive vasculitis. Arthritis Rheum. 2000 Feb;43(2):405-13.
32. Uetrecht J. Drug-induced lupus erythematosus. In: Kuhn A, Lehmann P, Ruzicka T, editors. Cutaneous lupus erythematosus., Berlin: Springer; 2005. P. 117-32.
33. Srivastava M, Rencic A, Diglio G, et al. Drug-induced, Ro/SSApositive cutaneous lupus erythematosus.Arch Dermatol. 2003 Jan;139(1):45-9.
34. Cassis TB, Callen JP. Bupropion-induced subacute cutaneous lupus erythematosus. Australas J Dermatol.2005 Nov;46(4):266-9.
35. Fenniche S, Dhaoui A, Ammar FB, et al. Acebutolol-induced subacute cutaneous lupus erythematosus.Skin Pharmacol Physiol.2005 Sep-Oct;18(5):230-3. Epub 2005 Jul 5.
36. Petri M, Kim MY, Kalunian KC, et al. Combined oral contraceptives in women with systemic lupus erythematosus. N Engl J Med. 2005 Dec 15;353(24):2550-8.
37. Petri M, Albritton J. Antibiotic allergy in systemic lupus erythematosus. J Rheumatol. 1992 Feb;19(2):265-9.
38. Capponi A, De Simone C, Guerriero C, et al. Ro/SSA-positive cutaneous lupus induced by carbamazepine. Arch Dermatol. 2005 Jan;141(1):103-4.
39. Buyon JP, Petri M, Kim MY, et al. The effect of combined estrogenprogesterone hormone replacement therapy on disease activity in systemic lupus erythematosus: a randomized trial. Ann Intern Med. 2005 Jun 21;142(12 Pt 1):953-62.
40. Almoallim H, Al-Ghamdi Y, Almaghrabi H, Alyasi O. Anti-tumor necrosis factor-αinduced systemic lupus erythematosus. Open Rheumatol J.2012;6:315-9. doi: 10.2174/1874312901206010315. Epub 2012 Nov 16.
41. Kontoyiannis D, Kollias G. Accelerated autoimmunity and lupus nephritis in NZB mice with an engineerd heterozygous deficiency in tumour necrosis factor.Eur J Immunol. 2000 Jul;30(7):2038-47.
42. Williams EL, Gadola S, Edwards CJ. Anti-TNF-induced lupus. Rheumatology (Oxford).2009 Jul;48(7):716-20. doi: 10.1093/rheumatology/kep080. Epub 2009 May 4.
43. Maczynska I, Millo B, RatajczakStefanska V, et al. Proinflammatory cytokine (IL-1beta, IL-6, IL-12, IL-18 and TNFalpha) levels in sera of patients with subacute cutaneous lupus erythematosus (SCLE). Immunol Lett.2006 Jan 15;102(1):79-82. Epub 2005 Aug 25.
44. Eriksson C, Engstrand S, Sundqvist KG, Rantapaa-Dahlqvist S. Autoantibody formation in patients with rheumatoid arthritis treated with anti-TNF alpha. Ann Rheum Dis. 2005 Mar;64(3):403-7. Epub 2004 Aug 5.
45. Wetter DA, Davis MDP. Lupus-like syndrome attributable to anti-tumor necrosis factor alpha therapy in 14 patients during an 8-year period at Mayo Clinic. Mayo Clin Proc.2009 Nov;84(11):979-84. doi: 10.4065/84.11.979.
46. Cambien B, Bergmeier W, Saffaripour S, et al. Antithrombotic activity of TNF-alpha. J Clin Invest.2003 Nov;112(10):1589-96.
47. Katz U, Zandman-Goddard G. Druginduced lupus: an update. Autoimmun Rev. 2010 Nov;10(1):46-50. doi: 10.1016/j.autrev. 2010.07.005. Epub 2010 Jul 23.
48. Thornhill J, Watson KD, Lord PA, et al. Drug-induced lupus in patients with inflammatory arthritis treared with TNF blocking agents: results from the BSR Biologics Register. BSR Abstracts; 2008.
49. Costa MF, Said NR, Zimmermann B. Drug-induced lupus due to anti-tumor necrosis factor alpha agents.Semin Arthritis Rheum. 2008 Jun;37(6):381-7. Epub 2007 Oct 30.
50. Bessissow T, Renard M, Hoffman I, et al. Review article: nonmalignant haematological complications of antitumour necrosis factor alpha therapy. Aliment Pharmacol Ther.2012; 36:212-323.
51. Bosch X, Saiz A, Ramos-Casals M. BIOGEAS Study Group. Monoclonal antibody therapy-associated neurological disorders. Nat Rev Neurol.2011 Mar;7(3):165-72. doi: 10.1038/nrneurol.2011.1. Epub 2011 Jan 25.
52. Ramos-Casal M, Brito-Zeron P, Munoz S, et al. Autoimmune diseases induced by TNF-targeted therapies. Analysis of 233 cases. Medicine (Baltimore). 2007 Jul; 86(4):242-51.
53. Charles PJ, Smeenk RJ, De Jong J, et al. Assessment of antibodies to double-stranded DNA induced in rheumatoid arthritis patients following treatment with infliximab, a monoclonal antibody to tumor necrosis factor. Arthritis Rheum.2000 Nov;43(11):2383-90.
54. Murav'ev YuV, Murav'eva LA. Tardy ideas on the use of biological agents in rheumatic diseases. Nauchno-prakticheskaya revmatologiya = Rheumatology Science and Practice.2016;54(3):361-6. (In Russ.). doi: 10.14412/1995-4484-2016-361-366
55. Murav'ev YuV, Lebedeva VV, Alamankina SYu. Infliximabinduced lupus-like syndrome in a female patient with rheumatoid arthritis (a case report): an accident or regularity? Nauchnoprakticheskaya revmatologiya = Rheumatology Science and Practice.2017;55(4):446-8. (In Russ.). doi: 10.14412/1995-4484-2017-446-448
56. Al'-Izzi M, Rida A. Case of cutaneous form of lupus erythematosus induced by the use of golimumab. Russkii meditsinskii zhurnal. 2017;(1):41-3. (In Russ.).
57. Nakamura Y, Izumi CI, Nakagawa Y, Hatta K. A case of effusive-constrictive pericarditis accompanying rheumatoid arthritis: the possibility of adverse effect of TNF-inhibitor therapy. Journal of Cardiology Cases. 2013;7:e8-e10.
58. Burmester GR, Pope JE. Novel treatment strategies in rheumatoid arthritis. Lancet. 2017 Jun 10;389(10086):2338-2348. doi: 10.1016/S0140-6736(17)31491-5.
59. Ramos-Casals M, Perez-Alvarez R, Diaz-Lagares C. Autoimmune diseases induced by biological agents: a double-edged sword? Autoimmun Rev.2010 Jan;9(3):188-93. doi: 10.1016/j.autrev.2009.10.003. Epub 2009 Oct 23.
60. Michalopoulos G, Vrakas S, Makris K, Tzathas C. Systemic lupus erythematosus in Crohn's disease: drug-induced or idiopathic? Ann Gastroenterol. 2015 Jul-Sep;28(3): 408-409.
61. McClung MR, Lewiecki EM, Geller ML, et al. Effect of denosumab on bone mineral density and biochemical markers of bone turnover: 8-year results of phase 2 clinical trial. Osteoporos Int.2013 Jan;24(1):227-35. doi: 10.1007/s00198-012-2052-4. Epub 2012 Jul 10.
62. Toroptsova NV, Nikitinskaya OA, Smirnov AV. Three years' experience with the biological agent denosumab used to treat women with postmenopausal osteoporosis: efficacy, safety and treatment adherence. Nauchno-prakticheskaya revmatologiya = Rheumatology Science and Practice. 2017;55(3):261-6. (In Russ.). doi: 10.14412/1995-4484-2017-261-266
63. Ramos-Casals M, Brito-Zeron P, Soto MJ, et al. Autoimmune diseases induced by TNF-targeted therapies. Best Pract Res Clin Rheumatol. 2008 Oct;22(5):847-61. doi: 10.1016/j.berh.2008.09.008.
64. Papagoras C, Voulgari PV, Drosos AA. Strategies after the failure of the first antitumor necrosis factor alpha agent in rheuma toid arthritis. Autoimmun Rev. 2010 Jun; 9(8):574-82. doi: 10.1016/j.autrev.2010.04.002. Epub 2010 Apr 28.
65. Almoallim H, Almasari A, Khadawardi H. Lupus Myositis with Normal Creatinine Kinase Levels Following Adalimumab Use in a Rheumatoid Arthritis Patient.Turk J Rheumatol.2011;26(4):328-32.
66. Williams VL, Cohen PR. TNF alpha antagonist-induced lupus-like syndrome: report and review of the literature with implications for treatment with alternative TNF alpha antagonists. Int J Dermatol.2011 May;50(5):619-25. doi: 10.1111/j.1365-4632.2011.04871.x.
67. Sturkenboom MC, Meier CR, Jick H, Stricker BH. Minocycline and lupus-like syndrome in acne patients.Arch Intern Med. 1999 Mar 8;159(5):493-7.
68. Murav'ev YuV, Gridina GI, Karateev DE. Thromboembolism is an unexpected poor response resulting from the use of the tumor necrosis factor inhibitor adalimumab. Nauchno-prakticheskaya revmatologiya = Rheumatology Science and Practice. 2013; 51(3):354-6. (In Russ.) doi: 10.14412/1995-4484-2013-1514
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For citations:
Klyukvina NG, Gunchikova VM, Novikova AM. Drug-induced lupus. Sovremennaya Revmatologiya=Modern Rheumatology Journal. 2018;12(4):32-41. (In Russ.) https://doi.org/10.14412/1996-7012-2018-4-32-41
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