The results of postgenomic analysis of a glucosamine sulfate molecule indicate the prospects of treatment for comorbidities
https://doi.org/10.14412/1996-7012-2018-4-129-136
Abstract
Postgenomic analysis of the effects of active ingredients of drugs involves the evaluation of the effects of relevant molecules on the transcription of genes (transcriptomes), on the changes in the activity of proteins (proteomes), and on the activity of molecular cascades (reactomes). The paper gives the results of applying the current chemoinformational approaches to the postgenomic analysis of the effects of glucosamine sulfate (GS). The main result of the investigation is to simultaneously establish the synergistic effect of GS on transcriptomes, proteomes, and reactomes. In particular, GS assists in reducing not only the transcription of genes involved in the NF-κB proinflammatory signaling cascade (NFKB2, TNFRSF1B, PYCARD, TRAF2, TNFSF12, etc.), but also the activity of proteomic proteins that transmit a signal at different levels of the NF-κB cascade (CD44, TLR4, ICAM1, NF-κB, JAK/STAT, etc.). The complex anti-inflammatory effect of GS in reducing the synthesis of proinflammatory cytokines and weakening their effects on the cells is pathogenetic in the treatment of not only osteoarthritis, but also comorbidities accompanied by chronic inflammation.
About the Authors
I. Yu. Torshin
Institute of Pharmacoinformatics, Federal Research Center «Informatics and Control», Russian Academy of Sciences.
Russian Federation
40, Vavilov St., Moscow 119333.
Russian Federation
40, Vavilov St., Moscow 119333.
O. A. Gromova
Institute of Pharmacoinformatics, Federal Research Center «Informatics and Control», Russian Academy of Sciences.
Russian Federation
Russian Federation
Olga Alekseevna Gromova.
40, Vavilov St., Moscow 119333.
A. M. Lila
V.A. Nasonova Research Institute of Rheumatology.
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522.
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522.
A. V. Naumov
Russian Gerontology Research and Clinical Center.
Russian Federation
16, First Leonov St., Moscow 129226.
Russian Federation
16, First Leonov St., Moscow 129226.
M. A. Sorokina
Dmitry Rogachev Federal Research and Clinical Center for Pediatric Hematology, Oncology, and Immunology.
Russian Federation
1, Samory Mashela St., Moscow 117997.
Russian Federation
1, Samory Mashela St., Moscow 117997.
K. V. Rudakov
Institute of Pharmacoinformatics, Federal Research Center «Informatics and Control», Russian Academy of Sciences.
Russian Federation
40, Vavilov St., Moscow 119333.
Russian Federation
40, Vavilov St., Moscow 119333.
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Review
For citations:
Torshin IY, Gromova OA, Lila AM, Naumov AV, Sorokina MA, Rudakov KV. The results of postgenomic analysis of a glucosamine sulfate molecule indicate the prospects of treatment for comorbidities. Sovremennaya Revmatologiya=Modern Rheumatology Journal. 2018;12(4):129-136. (In Russ.) https://doi.org/10.14412/1996-7012-2018-4-129-136
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