Chemoreactome analysis of the antithrombotic effects of glucosamine sulfate and nonsteroidal anti-inflammatory drugs
https://doi.org/10.14412/1996-7012-2019-1-129-134
Abstract
Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most effective medications in modern pharmacotherapy. At the same time, it has been established that NSAIDs can cause cardiovascular diseases. Glucosamine sulfate (GS) is used in the therapy of osteoarthritis and, according to experimental data; it can exert an antithrombotic effect. This paper evaluates the antithrombotic effects of GS and a number of NSAIDs (such as, acetylsalicylic acid (ASA), dexketoprofen, diclofenac, and meloxicam) through chemoreactome analysis. It has been found that the antithrombotic effects of GS can be on average only 1.5—3 times weaker than those of the NSAIDs studied. The findings may suggest that GS can enhance the antithrombotic effect of ASA, in particular in the presence of cardiovascular disease in patients with osteoarthritis.
About the Authors
O. A. Gromova
Federal Research Center «Informatics and Management», Russian Academy of Sciences
Russian Federation
Russian Federation
Olga Alekseevna Gromova
44, Vavilov St., Build. 2, Moscow 119333
I. Yu. Torshin
Federal Research Center «Informatics and Management», Russian Academy of Sciences
Russian Federation
Russian Federation
44, Vavilov St., Build. 2, Moscow 119333
A. M. Lila
V.A. Nasonova Research Institute of Rheumatology
Russian Federation
Russian Federation
34A, Kashirskoe Shosse, Moscow 115522
A. V. Naumov
Russian Gerontology Research and Clinical Center, N.I. Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
16, First Leonov St., Moscow 129226
K. V. Rudakov
Federal Research Center «Informatics and Management», Russian Academy of Sciences
Russian Federation
Russian Federation
44, Vavilov St., Build. 2, Moscow 119333
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Review
For citations:
Gromova OA, Torshin IY, Lila AM, Naumov AV, Rudakov KV. Chemoreactome analysis of the antithrombotic effects of glucosamine sulfate and nonsteroidal anti-inflammatory drugs. Sovremennaya Revmatologiya=Modern Rheumatology Journal. 2019;13(1):129-134. (In Russ.) https://doi.org/10.14412/1996-7012-2019-1-129-134
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