Эффективность ритуксимаба при железистых формах болезни Шёгрена по результатам международных клинических исследований
https://doi.org/10.14412/1996-7012-2020-1-85-92
Аннотация
Болезнь Шёгрена (БШ) – хроническое аутоиммунное заболевание, характеризующееся лимфоплазмоцитарной инфильтрацией экзокринных желез, ведущей к развитию их деструкции и прогрессирующей функциональной недостаточности. Распространенность БШ составляет около 5%, что делает ее одним из наиболее часто встречающихся аутоиммунных заболеваний. БШ зачастую имеет хроническое, медленно прогрессирующее течение.
В статье обсуждаются результаты международных клинических исследований, посвященных эффективности анти-В-клеточной терапии ритуксимабом (РТМ) при железистых формах БШ. Рассмотрено влияние данной терапии на различные иммунологические, гистологические показатели, субъективные и объективные параметры функции желез и активность заболевания. Обсуждаются возможные причины несоответствия результатов открытых клинических исследований и рандомизированных клинических испытаний, а также предикторы эффективности терапии ритуксимабом.
Установлено, что РТМ при БШ эффективно снижает В-клеточную активность, улучшает морфологическую картину в слюнных железах и некоторые внежелезистые проявления заболевания, уменьшает сухость и слабость. Отмечается большой потенциал анти-В-клеточных препаратов в терапии БШ.
Об авторе
А. В. Торгашина
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия
115522, , Москва, Каширское шоссе, 34А
Россия
115522, , Москва, Каширское шоссе, 34А
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