Перспективы использования тромбоцитарной плазмы в терапии ревматоидного артрита
https://doi.org/10.14412/1996-7012-2021-1-87-93
Аннотация
Представлен обзор данных литературы, посвященной механизмам действия богатой тромбоцитами плазмы (Platelet Rich Plasma, PRP) и опыту ее применения у пациентов с ревматоидным артритом (РА). Определено место PRP в системной и локальной терапии РА. Описаны химический состав PRP и структура включенных в нее органелл тромбоцитов. Дана оценка способов получения тромбоцитарной плазмы, содержащей различные концентрации ключевых факторов роста: тромбоцитарного фактора роста (PDGF), трансформирующего фактора роста α (TGFα), сосудистого эндотелиального фактора роста (VEGF), инсулиноподобного фактора роста (IGF) и эпидермального фактора роста (EGF). Рассмотрены варианты классификаций PRP, которые учитывают различия препаратов по составу и содержанию факторов роста. Проанализирован опыт внутрисуставного введения препаратов аутологичной плазмы пациентам с РА и синовитом. На основании приведенных данных сделано заключение о том, что PRP-терапия может оказаться эффективным инструментом купирования воспаления и стимуляции локальных процессов репарации поврежденных тканей сустава у больных РА. Дальнейшее изучение возможностей применения PRP-терапии и формирование ее протокола при РА позволят оказывать эффективную персонализированную помощь таким больным.
Ключевые слова
Об авторах
С. В. МаглеваныйРоссия
Сергей Владимирович Маглеваный
115522, Москва, Каширское шоссе, 34А
Е. А. Нарышкин
Россия
115522, Москва, Каширское шоссе, 34А
Е. В. Четина
Россия
115522, Москва, Каширское шоссе, 34А
М. А. Макаров
Россия
115522, Москва, Каширское шоссе, 34А
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