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Современная ревматология

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Остеоартрит и возраст. Роль старения в этиологии и патогенезе заболевания

https://doi.org/10.14412/1996-7012-2017-1-4-11

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Аннотация

В статье рассмотрены современные представления о механизмах развития и прогрессирования остеоартрита (ОА), дана дефиниция заболевания. На молекулярном и клеточном уровне описаны процессы, лежащие в основе старения и ОА, с акцентом на роль хронического неспецифического воспаления. Охарактеризованы возможные механизмы развития хронического возраст-ассоциированного воспаления (inflammaging/инфламэйджинг), базовым из которых является общее старение системы иммунитета. На основании данных литературы сделан вывод о том, что старение и ОА имеют общие каскады внутриклеточной транскрипции и патофизиологические механизмы: хроническое неспецифическое воспаление и метаболические нарушения существенно вовлечены в патогенез этих состояний. Отмечено, что метаболические и структурные изменения, происходящие в хряще и других тканях опорно-двигательного аппарата при старении, служат благоприятной платформой для дальнейшего развития и прогрессирования ОА

Об авторах

Л. В. Лучихина
ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России
Россия
117997, г. Москва, ул. Островитянова, 1


О. И. Мендель
ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России
Россия
117997, г. Москва, ул. Островитянова, 1


В. Мендель
ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России
Россия
117997, г. Москва, ул. Островитянова, 1


Г. Н. Голухов
ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России
Россия
117997, г. Москва, ул. Островитянова, 1


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Для цитирования:


Лучихина Л.В., Мендель О.И., Мендель В., Голухов Г.Н. Остеоартрит и возраст. Роль старения в этиологии и патогенезе заболевания. Современная ревматология. 2017;11(1):4-11. https://doi.org/10.14412/1996-7012-2017-1-4-11

For citation:


Luchikhina L.V., Mendel O.I., Mendel V., Golukhov G.N. Osteoarthritis and age. Role of aging in the etiology and pathogenesis of the disease. Modern Rheumatology Journal. 2017;11(1):4-11. (In Russ.) https://doi.org/10.14412/1996-7012-2017-1-4-11

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ISSN 1996-7012 (Print)
ISSN 2310-158X (Online)