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Современная ревматология

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Препараты гиалуроновой кислоты в лечении остеоартрита: все ли нам ясно?

https://doi.org/10.14412/1996-7012-2018-3-40-52

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Аннотация

Остеоартрит (ОА) – прогрессирующее заболевание суставов, вызывающее стойкую боль, ограничение функции суставов, потерю трудоспособности и социальной активности. Одним из популярных методов лечения ОА являются внутрисуставные (в/с) инъекции препаратов гиалуроновой кислоты (ГлК). Эта методика вошла в клиническую практику в начале 80-х годов прошлого века и получила повсеместное распространение. До настоящего времени не существует единого мнения о терапевтической ценности ГлК. Многие исследования подтверждают эффективность ГлК, причем в качестве не только симптоматического, но и структурномодифицирующего средства. Вместе в тем в некоторых работах действие ГлК было равным эффекту плацебо (в/с введение физиологического раствора) или лишь ненамного его превосходило. В обзоре рассмотрены механизм действия и сравнительная эффективность различных препаратов ГлК (низкои высокомолекулярной), а также безопасность их использования в реальной клинической практике.

Об авторах

А. Е. Каратеев
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия

Андрей Евгеньевич Каратеев

115522, Москва, Каширское шоссе, 34А




Е. Ю. Погожева
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия

115522, Москва, Каширское шоссе, 34А



В. Н. Амирджанова
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия

115522, Москва, Каширское шоссе, 34А



Е. С. Филатова
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
Россия

115522, Москва, Каширское шоссе, 34А



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Для цитирования:


Каратеев А.Е., Погожева Е.Ю., Амирджанова В.Н., Филатова Е.С. Препараты гиалуроновой кислоты в лечении остеоартрита: все ли нам ясно? Современная ревматология. 2018;12(3):40-52. https://doi.org/10.14412/1996-7012-2018-3-40-52

For citation:


Karateev A.E., Pogozheva Е.Y., Amirdzhanova V.N., Filatova Е.S. Hyaluronic acid preparations in the treatment of osteoarthritis: is it clear to us? Modern Rheumatology Journal. 2018;12(3):40-52. (In Russ.) https://doi.org/10.14412/1996-7012-2018-3-40-52

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ISSN 1996-7012 (Print)
ISSN 2310-158X (Online)